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                           November 22, 2021

       Scott Hutton
       Chief Executive Officer
       Biodesix, Inc.
       2970 Wilderness Place, Suite 100
       Boulder, Colorado 80301

                                                        Re: Biodesix, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed November 16,
2021
                                                            File No. 333-261095

       Dear Mr. Hutton:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jane
Park at 202-551-7439 with any questions.




                           Sincerely,


                           Division of Corporation Finance

                           Office of Life Sciences
       cc:                                              Samir Gandhi, Esq.